Magnetic resonance spectroscopy in preterm infants: association with neurodevelopmental outcomes

作者: Reina Hyodo , Yoshiaki Sato , Miharu Ito , Yuichiro Sugiyama , Chikako Ogawa

DOI: 10.1136/ARCHDISCHILD-2016-311403

关键词: Corrected AgePediatricsBiomarker (medicine)Neurodevelopmental delayGestational ageN-acetylaspartateMedicineFrontal white matter

摘要: Objective To compare magnetic resonance spectroscopy (MRS) metabolite ratios in preterm infants at term-equivalent age with those term and to evaluate the association between MRS metabolites neurodevelopmental outcomes 18 months corrected infants. Design We studied born a gestational Results Thirty-three 16 were enrolled this study. Preterm normal development showed significantly lower NAA/Cho frontal white matter than There no differences Cre/Cho At age, 9 mild developmental delay thalamus 24 development. Conclusions reduced (NAA/Cho) compared Decreased associated

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