Magnetic resonance spectroscopy in pediatric neuroradiology: clinical and research applications

作者: Ashok Panigrahy , Marvin D. Nelson , Stefan Blüml

DOI: 10.1007/S00247-009-1450-Z

关键词:

摘要: Magnetic resonance spectroscopy (MRS) offers a unique, noninvasive approach to assess pediatric neurological abnormalities at microscopic levels by quantifying cellular metabolites. The most widely available MRS method, proton ((1)H; hydrogen) spectroscopy, is FDA approved for general use and can be ordered clinicians neuroimaging studies if indicated. There are multitude of both acquisition post-processing methods that used in the implementation MR spectroscopy. challenging interpret because dramatic normal developmental changes occur metabolites, particularly first year life. Still, has been proven provide additional clinically relevant information several disease processes such as brain tumors, infectious processes, white matter disorders, neonatal injury. also powerful quantitative research tool. In this article, specific applications using will demonstrated relation injury tumor imaging.

参考文章(146)
Jorge A. Lazareff, Rakesh K. Gupta, Jeffry Alger, Variation of Post-treatment H-MRSI Choline Signal Intensity in Pediatric Gliomas Journal of Neuro-oncology. ,vol. 41, pp. 291- 298 ,(1999) , 10.1023/A:1006120623949
Taylor Js, Ogg Rj, Langston Jw, Proton MR spectroscopy of pediatric brain tumors. Neuroimaging Clinics of North America. ,vol. 8, pp. 753- ,(1998)
Harris H. Tallan, STUDIES ON THE DISTRIBUTION OF N-ACETYL-l-ASPARTIC ACID IN BRAIN Journal of Biological Chemistry. ,vol. 224, pp. 41- 45 ,(1957) , 10.1016/S0021-9258(18)65008-2
A. Tzika, L. Astrakas, M. Zarifi, N. Petridou, T. Young-Poussaint, L. Goumnerova, D. Zurakowski, D. Anthony, P. Black, Multiparametric MR assessment of pediatric brain tumors Neuroradiology. ,vol. 45, pp. 1- 10 ,(2003) , 10.1007/S00234-002-0865-0
N. M. Bolas, M. J. Blackledge, B. Rajagopalan, G. K. Radda, J. Moorcraft, P. Sutton, P. L. Hope, N. K. Ives, Spatially localized magnetic resonance spectroscopy of the brains of normal and asphyxiated newborns. Pediatrics. ,vol. 87, pp. 273- 282 ,(1991)
G. M. Enns, A. J. Barkovich, D. S. Rosenblatt, D. R. Fredrick, K. Weisiger, C. Ohnstad, S. Packman, Progressive neurological deterioration and MRI changes in cblC methylmalonic acidaemia treated with hydroxocobalamin. Journal of Inherited Metabolic Disease. ,vol. 22, pp. 599- 607 ,(1999) , 10.1023/A:1005517727451
Jacob Valk, Marjo S. van der Knaap, Magnetic Resonance of Myelin, Myelination, and Myelin Disorders ,(1989)
M. Wilke, A. Eidenschink, S. Muller-Weihrich, D. P. Auer, MR DIFFUSION IMAGING AND 1H SPECTROSCOPY IN A CHILD WITH MEDULLOBLASTOMA Acta Radiologica. ,vol. 42, pp. 39- 42 ,(2001) , 10.1034/J.1600-0455.2001.042001039.X