Eosinophils Promote Allergic Disease of the Lung by Regulating CD4+Th2 Lymphocyte Function

摘要: Eosinophils are primarily thought of as terminal effectors allergic responses and parasite elimination. However, limited studies suggest a more discrete immunomodulatory role for this leukocyte during these inflammatory responses. In investigation, we highlight the potential eosinophils to act APCs thus modulators by influencing Th2 cell function. response Ag provocation lung, rapidly trafficked sites deposition (airways lumen) presentation (lung-associated lymph nodes T cell-rich paracortical zones). from lung expressed class II MHC peptides, costimulatory molecules (CD80 CD86), internalized processed that was sampled within airway lumen. Ag-loaded promoted production IL-4, IL-5, IL-13 in cocultures with vitro-polarized cells induced IL-5 dose-dependent manner Ag-specific CD4(+) isolated mice. addition, primed cell-driven disease when transferred naive Thus, have not only activate release disease-modulating cytokines but also assist priming immune system This investigation highlights effector actively modulate inflammation amplifying