Development of tolerance to the excitatory effect of morphine and cross-tolerance to the inhibitory action of β-endorphin in the isolated rat vas deferens
作者： J Pablo Huidobro-Toro , H Miranda , F Huidobro , None
DOI: 10.1016/0024-3205(81)90160-0
关键词: Azidomorphine 、 Opiate 、 Morphine 、 (+)-Naloxone 、 Pharmacology 、 Etonitazene 、 Vas deferens 、 Neuromuscular transmission 、 Medicine 、 Cross-tolerance 、 General Pharmacology, Toxicology and Pharmaceutics 、 General Biochemistry, Genetics and Molecular Biology 、 General Medicine
摘要: Abstract In the isolated rat vas deferens, morphine caused an increase in neuromuscular twitch evoked by electrical stimulation. rats chronically treated with morphine, concentration of opiate required to cause a 50% was about 3 times larger than needed elicit same response vasa from placebo. The simultaneous administration naloxone plus partially antagonized tolerance development 22%. Morphine extended other opiate- like alkaloids such as etonitazene and derivative azidomorphine (CAM). contrast effects β-endorphin inhibited transmission. Vasa were 10 less sensitive inhibitory effect compared paired placebo controls. Chronic treatment conjuction significantly reduced cross-opiate 66%. Present results suggest that may interact at two different sites nerve terminals deferens.
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