Review of studies on metabolic genes and cancer in populations of African descent

摘要: Genetic polymorphisms described for a number of enzymes involved in the metabolism tobacco carcinogens and alcohol have been linked to increase cancer risk. Racial disparities between whites populations African descent are well documented. In addition differences access health care, both environment genetic factors their interaction may contribute increased risk minority populations. We reviewed literature identify case-control studies that included subjects descent. Meta-analyses investigating association metabolic genes were performed. Although several cancers studied, only one or two per gene each site published, with exception breast (CYP1A1 CYP1B1), lung (GSTM1, CYP1A1, NQO1), prostate (CYP3A4 A293G CYP17). Marginal statistically significant associations observed CYP3A4 CYP17 5′UTR cancer. Our findings support need additional breast, prostate, include larger participants. Because incidence mortality rates these rank highest among descent, concentrated research areas warranted.