Association between Alcohol Consumption and Cancers in the Chinese Population—A Systematic Review and Meta-Analysis

摘要: Background Alcohol consumption is increasing worldwide and associated with numerous cancers. This systematic review examined the role of alcohol in incidence cancer Chinese population. Methods Medline/PubMed, EMBASE, CNKI VIP were searched to identify relevant studies. Cohort case-control studies on effect use cancers included. Study quality was evaluated using Newcastle-Ottawa Scale. Data independently abstracted by two reviewers. Odds ratios (OR) or relative risks (RR) pooled RevMan 5.0. Heterogeneity Q test I-squared statistic. P<.01 considered statistically significant. Results Pooled results from cohort indicated that not gastric cancer, esophageal (EC) lung cancer. Meta-analysis showed a significant risk factor for five cancers; ORs 1.79 (99% CI, 1.47–2.17) EC, 1.40 1.19–1.64) 1.56 1.16–2.09) hepatocellular carcinoma, 1.21 1.00–1.46) nasopharyngeal 1.71 1.20–2.44) oral Pooled protective female breast gallbladder cancer: OR 0.76 0.60–0.97) 0.70 0.49–1.00) respectively. There no correlation between colorectal pancreatic ampulla Vater, prostate extrahepatic cholangiocarcinoma. Combined 1.78- 1.40-fold higher EC but significantly cancer. Conclusions Health programs focused limiting intake may be important control China. Further are needed examine interaction other factors populations.