CLPTM1L genetic polymorphisms and interaction with smoking and alcohol drinking in lung cancer risk: a case-control study in the Han population from northwest China.
作者： Xiaojie Xun , Huijuan Wang , Hua Yang , Hong Wang , Bo Wang
DOI: 10.1097/MD.0000000000000289
关键词:
摘要: Genetic variants of cleft lip and palate trans-membrane 1-like (CLPTM1L) genes in the p15.33 region chromosome 5 were previously identified to influence susceptibility lung cancer. We examined association single nucleotide polymorphisms (SNPs) CLPTM1L with cancer explored their potential effects on relationship between environmental risk factors (smoking, drinking) a Chinese Han population. genotyped 9 case-control study 228 cases 301 controls from northwest China. Odds ratios (ORs) 95% confidence intervals (CIs) calculated by unconditional logistic regression. that minor alleles rs451360, rs402710, rs31484 associated 0.52-fold, 0.76-fold, 0.70-fold decreased allelic model analysis, respectively. In genetic we found rs402710 rs401681 risk. Further stratification analysis showed rs380286 displayed significantly (OR=0.65, P=0.041) non-drinkers. addition, Haplotype "GTTATCTGT" was be (OR=0.50, P=0.033). Our results verified contribute Additionally, consumption alcohol may interact overall susceptibility.
sci-hub.se 参考文章(27)
Wanqing Chen, Siwei Zhang, Xiaonong Zou, Evaluation on the incidence, mortality and tendency of lung cancer in China. Thoracic Cancer. ,vol. 1, pp. 35- 40 ,(2010) , 10.1111/J.1759-7714.2010.00011.X
EUN YOUNG BAE, SHIN YUP LEE, BONG KYOON KANG, EUN JIN LEE, YI YOUNG CHOI, HYO-GYOUNG KANG, JIN EUN CHOI, HYO-SUNG JEON, WON KEE LEE, SHIN KAM, KYUNG MIN SHIN, GUANG JIN, SEUNG SOO YOO, JAEHEE LEE, SEUNG ICK CHA, CHANG HO KIM, TAE HOON JUNG, JAE YONG PARK, Replication of results of genome‐wide association studies on lung cancer susceptibility loci in a Korean population Respirology. ,vol. 17, pp. 699- 706 ,(2012) , 10.1111/J.1440-1843.2012.02165.X
J M. Bland, Statistics Notes: The odds ratio BMJ. ,vol. 320, pp. 1468- 1468 ,(2000) , 10.1136/BMJ.320.7247.1468
Shivanand R. Patil, Linda K. Ashworth, Jaqueline T. Hecht, Jeffrey C. Murray, Koh-ichiro Yoshiura, Junichiro Machida, Sandra Daack-Hirsch, Characterization of a Novel Gene Disrupted by a Balanced Chromosomal Translocation t(2;19)(q11.2;q13.3) in a Family with Cleft Lip and Palate Genomics. ,vol. 54, pp. 231- 240 ,(1998) , 10.1006/GENO.1998.5577
Ying Li, Huan Yang, Jia Cao, Association between Alcohol Consumption and Cancers in the Chinese Population—A Systematic Review and Meta-Analysis PLOS ONE. ,vol. 6, ,(2011) , 10.1371/JOURNAL.PONE.0018776
Kazue Yamamoto, Aikou Okamoto, Seiji Isonishi, Kazunori Ochiai, Yasuyuki Ohtake, A Novel Gene, CRR9, Which Was Up-Regulated in CDDP-Resistant Ovarian Tumor Cell Line, Was Associated with Apoptosis Biochemical and Biophysical Research Communications. ,vol. 280, pp. 1148- 1154 ,(2001) , 10.1006/BBRC.2001.4250
Zhenhua Ni, Kun Tao, Guo Chen, Qingge Chen, Jianmin Tang, Xuming Luo, Peihao Yin, Jihong Tang, Xiongbiao Wang, CLPTM1L Is Overexpressed in Lung Cancer and Associated with Apoptosis PLoS ONE. ,vol. 7, pp. e52598- ,(2012) , 10.1371/JOURNAL.PONE.0052598
James D McKay, Rayjean J Hung, Valerie Gaborieau, Paolo Boffetta, Amelie Chabrier, Graham Byrnes, David Zaridze, Anush Mukeria, Neonilia Szeszenia-Dabrowska, Jolanta Lissowska, Peter Rudnai, Eleonora Fabianova, Dana Mates, Vladimir Bencko, Lenka Foretova, Vladimir Janout, John McLaughlin, Frances Shepherd, Alexandre Montpetit, Steven Narod, Hans E Krokan, Frank Skorpen, Maiken Bratt Elvestad, Lars Vatten, Inger Njølstad, Tomas Axelsson, Chu Chen, Gary Goodman, Matt Barnett, Melissa M Loomis, Jan Lubiñski, Joanna Matyjasik, Marcin Lener, Dorota Oszutowska, John Field, Triantafillos Liloglou, George Xinarianos, Adrian Cassidy, Diana Zelenika, Anne Boland, Marc Delepine, Mario Foglio, Doris Lechner, Fumihiko Matsuda, Helene Blanche, Ivo Gut, Simon Heath, Mark Lathrop, Paul Brennan, None, Lung cancer susceptibility locus at 5p15.33 Nature Genetics. ,vol. 40, pp. 1404- 1406 ,(2008) , 10.1038/NG.254
Zhibin Hu, Chen Wu, Yongyong Shi, Huan Guo, Xueying Zhao, Zhihua Yin, Lei Yang, Juncheng Dai, Lingmin Hu, Wen Tan, Zhiqiang Li, Qifei Deng, Jiucun Wang, Wei Wu, Guangfu Jin, Yue Jiang, Dianke Yu, Guoquan Zhou, Hongyan Chen, Peng Guan, Yijiang Chen, Yongqian Shu, Lin Xu, Xiangyang Liu, Li Liu, Ping Xu, Baohui Han, Chunxue Bai, Yuxia Zhao, Haibo Zhang, Ying Yan, Hongxia Ma, Jiaping Chen, Mingjie Chu, Feng Lu, Zhengdong Zhang, Feng Chen, Xinru Wang, Li Jin, Jiachun Lu, Baosen Zhou, Daru Lu, Tangchun Wu, Dongxin Lin, Hongbing Shen, A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese Nature Genetics. ,vol. 43, pp. 792- 796 ,(2011) , 10.1038/NG.875
Hidemi Ito, James D. McKay, Satoyo Hosono, Toyoaki Hida, Yasushi Yatabe, Tetsuya Mitsudomi, Paul Brennan, Hideo Tanaka, Keitaro Matsuo, Association between a Genome-Wide Association Study-Identified Locus and the Risk of Lung Cancer in Japanese Population Journal of Thoracic Oncology. ,vol. 7, pp. 790- 798 ,(2012) , 10.1097/JTO.0B013E3182475028