Lung cancer susceptibility locus at 5p15.33

作者: James D McKay , Rayjean J Hung , Valerie Gaborieau , Paolo Boffetta , Amelie Chabrier

DOI: 10.1038/NG.254

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摘要: We carried out a genome-wide association study of lung cancer (3,259 cases and 4,159 controls), followed by replication in 2,899 cases and 5,573 controls. Two uncorrelated disease …

参考文章(15)
Scott L. Weinrich, Ron Pruzan, Libin Ma, Michel Ouellette, Valeric M. Tesmer, Shawn E. Holt, Andrea G. Bodnar, Serge Lichtsteiner, Nam W. Kim, James B. Trager, Rebecca D. Taylor, Ruben Carlos, William H. Andrews, Woodring E. Wright, Jerry W. Shay, Calvin B. Harley, Gregg B. Morin, Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT Nature Genetics. ,vol. 17, pp. 498- 502 ,(1997) , 10.1038/NG1297-498
Christopher I Amos, Xifeng Wu, Peter Broderick, Ivan P Gorlov, Jian Gu, Timothy Eisen, Qiong Dong, Qing Zhang, Xiangjun Gu, Jayaram Vijayakrishnan, Kate Sullivan, Athena Matakidou, Yufei Wang, Gordon Mills, Kimberly Doheny, Ya-Yu Tsai, Wei Vivien Chen, Sanjay Shete, Margaret R Spitz, Richard S Houlston, Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1 Nature Genetics. ,vol. 40, pp. 616- 622 ,(2008) , 10.1038/NG.109
M. Armanios, J.-L. Chen, Y.-P. C. Chang, R. A. Brodsky, A. Hawkins, C. A. Griffin, J. R. Eshleman, A. R. Cohen, A. Chakravarti, A. Hamosh, C. W. Greider, Haploinsufficiency of telomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenita Proceedings of the National Academy of Sciences of the United States of America. ,vol. 102, pp. 15960- 15964 ,(2005) , 10.1073/PNAS.0508124102
Kazue Yamamoto, Aikou Okamoto, Seiji Isonishi, Kazunori Ochiai, Yasuyuki Ohtake, A Novel Gene, CRR9, Which Was Up-Regulated in CDDP-Resistant Ovarian Tumor Cell Line, Was Associated with Apoptosis Biochemical and Biophysical Research Communications. ,vol. 280, pp. 1148- 1154 ,(2001) , 10.1006/BBRC.2001.4250
Ralf Janknecht, On the road to immortality: hTERT upregulation in cancer cells FEBS Letters. ,vol. 564, pp. 9- 13 ,(2004) , 10.1016/S0014-5793(04)00356-4
Douglas Hanahan, Robert A Weinberg, The hallmarks of cancer. Cell. ,vol. 100, pp. 57- 70 ,(2000) , 10.1016/S0092-8674(00)81683-9
Carol W. Greider, Elizabeth H. Blackburn, A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature. ,vol. 337, pp. 331- 337 ,(1989) , 10.1038/337331A0
Sharon A. Savage, Brian J. Stewart, Andrew Eckert, Maureen Kiley, Jason S. Liao, Stephen J. Chanock, Genetic variation, nucleotide diversity, and linkage disequilibrium in seven telomere stability genes suggest that these genes may be under constraint†‡ Human Mutation. ,vol. 26, pp. 343- 350 ,(2005) , 10.1002/HUMU.20226
Sylvie Lantuéjoul, Caroline Salon, Jean-Charles Soria, Elisabeth Brambilla, Telomerase expression in lung preneoplasia and neoplasia. International Journal of Cancer. ,vol. 120, pp. 1835- 1841 ,(2007) , 10.1002/IJC.22473
Thorgeir E Thorgeirsson, Frank Geller, Patrick Sulem, Thorunn Rafnar, Anna Wiste, Kristinn P Magnusson, Andrei Manolescu, Gudmar Thorleifsson, Hreinn Stefansson, Andres Ingason, Simon N Stacey, Jon T Bergthorsson, Steinunn Thorlacius, Julius Gudmundsson, Thorlakur Jonsson, Margret Jakobsdottir, Jona Saemundsdottir, Olof Olafsdottir, Larus J Gudmundsson, Gyda Bjornsdottir, Kristleifur Kristjansson, Halla Skuladottir, Helgi J Isaksson, Tomas Gudbjartsson, Gregory T Jones, Thomas Mueller, Anders Gottsäter, Andrea Flex, Katja KH Aben, Femmie De Vegt, Peter FA Mulders, Dolores Isla, Maria J Vidal, Laura Asin, Berta Saez, Laura Murillo, Thorsteinn Blondal, Halldor Kolbeinsson, Jon G Stefansson, Ingunn Hansdottir, Valgerdur Runarsdottir, Roberto Pola, Bengt Lindblad, Andre M Van Rij, Benjamin Dieplinger, Meinhard Haltmayer, Jose I Mayordomo, Lambertus A Kiemeney, Stefan E Matthiasson, Hogni Oskarsson, Thorarinn Tyrfingsson, Daniel F Gudbjartsson, Jeffrey R Gulcher, Steinn Jonsson, Unnur Thorsteinsdottir, Augustine Kong, Kari Stefansson, None, A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature. ,vol. 452, pp. 638- 642 ,(2008) , 10.1038/NATURE06846