Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1

作者: Christopher I Amos , Xifeng Wu , Peter Broderick , Ivan P Gorlov , Jian Gu

DOI: 10.1038/NG.109

关键词: BiologyGenetic linkageCHRNA5Linkage disequilibriumHaplotypeSingle-nucleotide polymorphismLung cancerLung cancer susceptibilityCancerGenetics

摘要: … We used HelixTree for preliminary analyses and for initial data manipulation; we then transferred data to PLINK 17 and EIGENSTRAT 20 . We evaluated the association of markers with …

参考文章(23)
Li Shu-Chung Cheng, Guillermina Lozano, Christopher I. Amos, Xiangjun Gu, Louise C. Strong, Shih-Jen Hwang, Lung cancer risk in germline p53 mutation carriers: association between an inherited cancer predisposition, cigarette smoking, and cancer risk Human Genetics. ,vol. 113, pp. 238- 243 ,(2003) , 10.1007/S00439-003-0968-7
B Devlin, Kathryn Roeder, Larry Wasserman, Genomic Control, a New Approach to Genetic-Based Association Studies Theoretical Population Biology. ,vol. 60, pp. 155- 166 ,(2001) , 10.1006/TPBI.2001.1542
BM Sanders, M Jay, GJ Draper, EM Roberts, Non-ocular cancer in relatives of retinoblastoma patients. British Journal of Cancer. ,vol. 60, pp. 358- 365 ,(1989) , 10.1038/BJC.1989.285
Qunzhou Zhang, Xudong Tang, Zuo-Feng Zhang, Rita Velikina, Shihong Shi, Anh D. Le, Nicotine Induces Hypoxia-Inducible Factor-1α Expression in Human Lung Cancer Cells via Nicotinic Acetylcholine Receptor–Mediated Signaling Pathways Clinical Cancer Research. ,vol. 13, pp. 4686- 4694 ,(2007) , 10.1158/1078-0432.CCR-06-2898
Masataka Takemiya, Satoshi Shiraishi, Tatsuyuki Teramoto, Yoshiharu Miki, Bloom's syndrome with porokeratosis of Mibeili and multiple cancers of the skin, lung and colon Clinical Genetics. ,vol. 31, pp. 35- 44 ,(2008) , 10.1111/J.1399-0004.1987.TB02764.X
Scott F. Saccone, Anthony L. Hinrichs, Nancy L. Saccone, Gary A. Chase, Karel Konvicka, Pamela A.F. Madden, Naomi Breslau, Eric O. Johnson, Dorothy Hatsukami, Ovide Pomerleau, Gary E. Swan, Alison M. Goate, Joni Rutter, Sarah Bertelsen, Louis Fox, Douglas Fugman, Nicholas G. Martin, Grant W. Montgomery, Jen C. Wang, Dennis G. Ballinger, John P. Rice, Laura Jean Bierut, Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs Human Molecular Genetics. ,vol. 16, pp. 36- 49 ,(2007) , 10.1093/HMG/DDL438
Steinn Jonsson, Unnur Thorsteinsdottir, Daniel F Gudbjartsson, Hjortur H Jonsson, Kristleifur Kristjansson, Sigurdur Arnason, Vilmundur Gudnason, Helgi J Isaksson, Jonas Hallgrimsson, Jeffrey R Gulcher, Laufey T Amundadottir, Augustine Kong, Kari Stefansson, Familial Risk of Lung Carcinoma in the Icelandic Population JAMA. ,vol. 292, pp. 2977- 2983 ,(2004) , 10.1001/JAMA.292.24.2977
Emily L. Webb, Matthew F. Rudd, Gabrielle S. Sellick, Rachid El Galta, Lara Bethke, Wendy Wood, Olivia Fletcher, Steven Penegar, Laura Withey, Mobshra Qureshi, Nichola Johnson, Ian Tomlinson, Richard Gray, Julian Peto, Richard S. Houlston, Search for low penetrance alleles for colorectal cancer through a scan of 1467 non-synonymous SNPs in 2575 cases and 2707 controls with validation by kin-cohort analysis of 14 704 first-degree relatives Human Molecular Genetics. ,vol. 15, pp. 3263- 3271 ,(2006) , 10.1093/HMG/DDL401
Andrew D Skol, Laura J Scott, Gonçalo R Abecasis, Michael Boehnke, Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies Nature Genetics. ,vol. 38, pp. 209- 213 ,(2006) , 10.1038/NG1706