Lung cancer risk in germline p53 mutation carriers: association between an inherited cancer predisposition, cigarette smoking, and cancer risk

摘要: We recently observed a significantly increased risk for lung cancer in carriers of p53 germline mutations. Because cigarette smoking is known to play an important role increasing the general population, we wanted determine people with genetic susceptibility based on mutation. studied 1263 from 97 families enrolled cohort study systematically ascertained through childhood soft-tissue sarcoma patients treated at M.D. Anderson Cancer Center, University Texas, between 1944 and 1975. assessed incidence smoking-related cancers 33 mutations 1,230 noncarriers whether there was association inherited predisposition, smoking, risk. analyzed mutation status, other by Kaplan-Meier method Cox proportional hazards model adjustments birth year, race, sex. In model, incorporated robust variance estimation adjust familial correlation. variety histological types Mutation who smoked had 3.16-fold (95% confidence interval =1.48–6.78) higher than did not smoke. Our results demonstrate that increases This finding could be useful designing strategies early detection treatment individuals this predisposition.