A variant associated with nicotine dependence, lung cancer and peripheral arterial disease.
作者： Thorgeir E Thorgeirsson , Frank Geller , Patrick Sulem , Thorunn Rafnar , Anna Wiste
DOI: 10.1038/NATURE06846
关键词: Odds ratio 、 Population 、 Oncology 、 Internal medicine 、 Lung cancer 、 Lung cancer susceptibility 、 Nicotine 、 Risk factor 、 CHRNA5 、 Medicine 、 Epidemiology
摘要: … Here we identify a common variant in the nicotinic acetylcholine receptor gene cluster on … 20 , highlighting the role of nicotine addiction in the pathology of other serious diseases. …
ru.nl
harvard.edu
core.ac.uk
lsh.is
nature.com参考文章(42)
ERNEST L. WYNDER, Tobacco smoking as a possible etiologic factor in bronchiogenic carcinoma; a study of 684 proved cases. JAMA. ,vol. 143, pp. 329- 336 ,(1950) , 10.1001/JAMA.1950.02910390001001
W Berrettini, X Yuan, F Tozzi, K Song, C Francks, H Chilcoat, D Waterworth, P Muglia, V Mooser, α-5/α-3 nicotinic receptor subunit alleles increase risk for heavy smoking Molecular Psychiatry. ,vol. 13, pp. 368- 373 ,(2008) , 10.1038/SJ.MP.4002154
Pamela A. F. Madden, Andrew C. Heath, Nancy L. Pedersen, Jaakko Kaprio, Markku J. Koskenvuo, Nicholas G. Martin, The genetics of smoking persistence in men and women: a multicultural study. Behavior Genetics. ,vol. 29, pp. 423- 431 ,(1999) , 10.1023/A:1021674804714
Struan F A Grant, Gudmar Thorleifsson, Inga Reynisdottir, Rafn Benediktsson, Andrei Manolescu, Jesus Sainz, Agnar Helgason, Hreinn Stefansson, Valur Emilsson, Anna Helgadottir, Unnur Styrkarsdottir, Kristinn P Magnusson, G Bragi Walters, Ebba Palsdottir, Thorbjorg Jonsdottir, Thorunn Gudmundsdottir, Arnaldur Gylfason, Jona Saemundsdottir, Robert L Wilensky, Muredach P Reilly, Daniel J Rader, Yu Bagger, Claus Christiansen, Vilmundur Gudnason, Gunnar Sigurdsson, Unnur Thorsteinsdottir, Jeffrey R Gulcher, Augustine Kong, Kari Stefansson, Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes Nature Genetics. ,vol. 38, pp. 320- 323 ,(2006) , 10.1038/NG1732
R. Doll, A. B. Hill, Study of the Aetiology of Carcinoma of the Lung BMJ. ,vol. 2, pp. 1271- 1286 ,(1952) , 10.1136/BMJ.2.4797.1271
Thorgeir E. Thorgeirsson, Högni Oskarsson, Natasa Desnica, Jelena Pop Kostic, Jon G. Stefansson, Halldor Kolbeinsson, Eirikur Lindal, Nikolai Gagunashvili, Michael L. Frigge, Augustine Kong, Kari Stefansson, Jeffrey R. Gulcher, Anxiety with Panic Disorder Linked to Chromosome 9q in Iceland American Journal of Human Genetics. ,vol. 72, pp. 1221- 1230 ,(2003) , 10.1086/375141
Laura Jean Bierut, Joseph F. Cubells, William G. Iacono, Ming D. Li, Pamela A. F. Madden, Elliot C. Nelson, Jonathan D. Pollock, Joni L. Rutter, Gary E. Swan, Michael Vanyukov, Genetic Research and Smoking Behavior JAMA. ,vol. 297, pp. 809- 810 ,(2007) , 10.1001/JAMA.297.8.809
Jeffrey C Barrett, Lon R Cardon, None, Evaluating coverage of genome-wide association studies Nature Genetics. ,vol. 38, pp. 659- 662 ,(2006) , 10.1038/NG1801
I. P. Stolerman, M. J. Jarvis, The scientific case that nicotine is addictive Psychopharmacology. ,vol. 117, pp. 2- 10 ,(1995) , 10.1007/BF02245088
D. M. Parkin, F. Bray, J. Ferlay, P. Pisani, Global cancer statistics, 2002. CA: A Cancer Journal for Clinicians. ,vol. 55, pp. 74- 108 ,(2005) , 10.3322/CANJCLIN.55.2.74