Genetic Susceptibility to Lung Cancer

摘要: Although tobacco smoke, with its numerous carcinogens and procarcinogens, is strongly linked to lung cancer risk, many people have similar smoke other environmental exposures do not develop cancer. Also, the histologic types occurring in never-smokers differs from those smokers. People are thought different susceptibilities risk factors, including factors; a genetic basis for differing factor has been proposed based on observation that appear be inherited aggregation of cancers within families. The concept explains why some little or no exposure Further, differences, gene-environment interactions, factors could help explain exposure, at younger ages; heavy smokers cancer; patients strong family histories Studies associated tobacco-related identified several polymorphisms as potentially increasing risk. These involve genes primarily metabolism suppression mutations induced by carcinogens. Tobacco-associated vs. nontobacco-associated cancers, gender geographic differences all confounding evaluation involved There much remains discovered, studies such these must continue order further elucidate relationship between how relationships may used prevent cancer, affect treatment responses, improve clinical outcomes.