A case-control study of cytochrome P450 1A1, glutathione S-transferase M1, cigarette smoking and lung cancer susceptibility (Massachusetts, United States)
作者： Montserrat García-Closas , Karl T. Kelsey , Karl T. Kelsey , John K. Wiencke , Xiping Xu
关键词: Genotype 、 Carcinogen 、 Physiology 、 Confidence interval 、 Lung cancer 、 Tobacco smoke 、 Case-control study 、 Epidemiology 、 Lung cancer susceptibility 、 Pathology 、 Medicine
摘要: Cytochrome P450 1A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1)genetic polymorphisms are involved in the activation detoxification ofchemical carcinogens found tobacco smoke; thus they may influence hostsusceptibility to lung cancer. In this study at Massachusetts GeneralHospital (Boston, MA, USA) of 416 cases 446 controls (mostly White) weevaluated association between CYP1A1 MspI GSTM1 andlung cancer risk, their interaction with cigarette smoke. The MspIheterozygous genotype was present 18 percent 16 ofcontrols, one were homozygousvariant. null detected 54 52percent controls. After adjusting for age, gender, pack-years smoking,and years since quitting smoking, while neither heterozygousgenotype alone nor associated asignificant increas e having both genetic traits wasassociated a twofold increase risk (95 confidence interval[CI] = 1.0-3.4). Our data did not provide enough evidence substantialmodification effect on by CYP1A1MspI genotypes. However, limitations our preclude aconclusion about potential interaction.
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sci-hub.se 参考文章(37)
D W Nebert, O W McBride, K Ikeya, D D Petersen, A E Bale, H H Smith, C E McKinney, Human CYP1A1 gene: cosegregation of the enzyme inducibility phenotype and an RFLP. American Journal of Human Genetics. ,vol. 48, pp. 720- 725 ,(1991)
F. Peter Guengerich, Mammalian cytochromes P-450 CRC Press. ,(1987)
Nikolaos Drakoulis, Manfred Nitz, Jürgen Brockmöller, Ivar Roots, Reinhold Kerb, Genotype and Phenotype of Glutathione S-Transferase Class µ Isoenzymes µ and ψ in Lung Cancer Patients and Controls Cancer Research. ,vol. 53, pp. 1004- 1011 ,(1993)
Kei Nakachi, Kazue Imai, Kaname Kawajiri, Shin Ichi Hayashi, Polymorphisms of the CYP1A1 and Glutathione S-Transferase Genes Associated with Susceptibility to Lung Cancer in Relation to Cigarette Dose in a Japanese Population Cancer Research. ,vol. 53, pp. 2994- 2999 ,(1993)
Shin-ichi Hayashi, Junko Watanabe, Kei Nakachi, Kaname Kawajiri, Genetic linkage of lung cancer-associated MspI polymorphisms with amino acid replacement in the heme binding region of the human cytochrome P450IA1 gene Journal of Biochemistry. ,vol. 110, pp. 407- 411 ,(1991) , 10.1093/OXFORDJOURNALS.JBCHEM.A123594
J To-Figueras, J Gomez-Catalan, J Corbella, M Rodamilans, E Huguet, M Gene, J Firvida, J Estape, M Fuentes, C Galan, Glutathione-S-Transferase M1 and codon 72 p53 polymorphisms in a northwestern Mediterranean population and their relation to lung cancer susceptibility. Cancer Epidemiology, Biomarkers & Prevention. ,vol. 5, pp. 337- 342 ,(1996)
J K Wiencke, D C Christiani, K T Kelsey, J C Wain, X Xu, Cytochrome P450 CYP1A1 MspI polymorphism and lung cancer susceptibility. Cancer Epidemiology, Biomarkers & Prevention. ,vol. 5, pp. 687- 692 ,(1996)
Greg Cosma, Frances Crofts, Emanuela Taioli, Paolo Toniolo, Seymour Garte, Relationship between genotype and function of the human CYP1A1 gene Journal of Toxicology and Environmental Health. ,vol. 40, pp. 309- 316 ,(1993) , 10.1080/15287399309531796
Sisko Anttila, Ari Hirvonen, Kirsti Husgafvel-Pursiainen, Antti Karjalainen, Tuula Nurminen, Harri Vainio, Combined effect of CYP1A1 inducibility and GSTM1 polymorphism on histological type of lung cancer Carcinogenesis. ,vol. 15, pp. 1133- 1135 ,(1994) , 10.1093/CARCIN/15.6.1133
Kaname Kawajiri, Kei Nakachi, Kazue Imai, Akira Yoshii, Nahomi Shinoda, Junko Watanabe, Identification of genetically high risk individuals to lung cancer by DNA polymorphisms of the cytochrome P45 0IA1 gene FEBS Letters. ,vol. 263, pp. 131- 133 ,(1990) , 10.1016/0014-5793(90)80721-T