NAT2 and CYP1A2 polymorphisms and lung cancer risk in relation to smoking status.
作者： Kayo Kumar Osawa , Noriaki Tsubota , Juro Takahashi , Yasunori Osawa , Akimitsu Tsutou
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摘要: We investigated the associations between lung cancer and gene polymorphisms of drug metabolizing enzymes, containing cytochrome P450 1A1 (CYP1A1), 1A2 (CYP1A2), glutathione S-transferase class mu (GSTM1), N-acetyltransferase 2 (NAT2). The study involved 113 patients 121 noncancer controls divided into never, light heavy smokers according to pack-years smoking in Japanese by using PCR-RFLP. For smokers, risk NAT2 intermediate-slow was significantly increased [the adjusted odds ratio (OR): 10.9, 95% confidence intervals (95%CI): 1.75-67.5, P-value: 0.010]. Moreover, never having joint genotypes CYP1A2*1F A/A also associated with (OR: 4.95, CI: 1.19-20.6, 0.028). suggested that activity were at highest for gene-gene interaction based on high CYP1A2 would be a among smokers.
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