CYP2D6 gene polymorphism in Caucasian smokers

作者: L. Laforest , H. Wikman , S. Benhamou , S.T. Saarikoski , C. Bouchardy

DOI: 10.1016/S0959-8049(00)00185-4

关键词: BiologyCYP2D6Internal medicineCarcinomaLung cancerCase-control studyGenotypeRespiratory diseasePopulationPathologyOdds ratioOncology

摘要: … Discrepant phenotype–genotype determinations were initially observed for 8 out of our 129 … with two recent studies on phenotype–genotype relationships indicating that neither the …

参考文章(37)
Christine Bouchardy, Simone Benhamou, Pierre Dayer, The effect of tobacco on lung cancer risk depends on CYP2D6 activity. Cancer Research. ,vol. 56, pp. 251- 253 ,(1996)
Norman E. Breslow, N. E. Day, The analysis of case-control studies International Agency for Research on Cancer. ,(1980)
C Sachse, S Bauer, J Brockmöller, I Roots, Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences. American Journal of Human Genetics. ,vol. 60, pp. 284- 295 ,(1997)
R F Tyndale, E M Sellers, E S Messina, A Major Role for CYP2A6 in Nicotine C-Oxidation by Human Liver Microsomes Journal of Pharmacology and Experimental Therapeutics. ,vol. 282, pp. 1608- 1614 ,(1997)
S. Kato, E. D. Bowman, A. M. Harrington, B. Blomeke, P. G. Shields, Human Lung Carcinogen—DNA Adduct Levels Mediated by Genetic Polymorphisms In Vivo Journal of the National Cancer Institute. ,vol. 87, pp. 902- 907 ,(1995) , 10.1093/JNCI/87.12.902
Ernst-Ulrich Griese, Ulrich M. Zanger, Ulrich Brudermanns, Andrea Gaedigk, Gerd Mikus, Klaus M??rike, Thomas St??ven, Michel Eichelbaum, Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population Pharmacogenetics. ,vol. 8, pp. 15- 26 ,(1998) , 10.1097/00008571-199802000-00003
Richard J. Bertz, G. Richard Granneman, Use of In Vitro and In Vivo Data to Estimate the Likelihood of Metabolic Pharmacokinetic Interactions Clinical Pharmacokinectics. ,vol. 32, pp. 210- 258 ,(1997) , 10.2165/00003088-199732030-00004
Karl Walter Bock, Dieter Schrenk, Adelheid Forster, Ernst-Ulrich Griese, Klaus M??rike, Dierk Brockmeier, Michel Eichelbaum, The influence of environmental and genetic factors on CYP2D6, CYP1A2 and UDP-glucuronosyltransferases in man using sparteine, caffeine, and paracetamol as probes. Pharmacogenetics. ,vol. 4, pp. 209- 218 ,(1994) , 10.1097/00008571-199408000-00005