Polymorphism of selected enzymes involved in detoxification and biotransformation in relation to lung cancer.
作者： Peter Gresner , Jolanta Gromadzinska , Wojciech Wasowicz
DOI: 10.1016/J.LUNGCAN.2007.02.002
关键词: Genetics 、 EPHX1 、 Biology 、 Genetic predisposition 、 Lung cancer 、 Lung cancer susceptibility 、 Population 、 Cancer 、 Glutathione peroxidase 、 Microsomal epoxide hydrolase
摘要: Available data indicate that there are significant differences in individual susceptibility to lung cancer within the human population. It is believed be underlie by inherited genetic predispositions related polymorphism of several enzymes involved detoxification and xenobiotic metabolism. In this review, we collect discuss evidence reported up date on association between cytochromes P450, N-acetyltransferase, glutathione S-transferases, microsomal epoxide hydrolase, NAD(P)H:quinone oxidoreductase, myeloperoxidase peroxidase. All these genes might appear candidates for genes, nevertheless, present state art still offers only a limited explanation link such polymorphisms increased risk cancer.
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