Microsomal epoxide hydrolase polymorphisms and lung cancer risk in non-Hispanic whites.

摘要: Microsomal epoxide hydrolase (mEPHX) is a critical metabolic enzyme involved in the activation and subsequent detoxification of specific tobacco carcinogens. mEPHX harbors polymorphisms exon 3 4 that modulate enzymatic activity. The polymorphism decreases activity, whereas increases We hypothesized lung cancer risk. Using case-control study design restriction fragment length polymerase chain reaction assay, we determined polymorphic genotypes 181 cases among non-Hispanic whites 163 controls (matched for age, sex, ethnicity, smoking history). Our results showed variant allele increased overall risk by 56% (odds ratio [OR] = 1.56, 95% confidence interval [CI] = 0.99–2.46). Additionally, estimates were elevated significantly younger people (< 64 yr) (OR = 2.27, CI = 1.15–4.50) current smokers (OR = 2.22, CI = 1.06–4.65). had no effect (OR = 0.88, CI = 0.56–1.38), but there was 53% protective (OR = 0.47, CI = 0.22–0.99) people. When analyzed together, those with high activity genotype an 1.72 (95% CI = 0.90–3.29). This also evident only These findings suggest these alleles modulates © 2002 Wiley-Liss, Inc.