The effect of tobacco on lung cancer risk depends on CYP2D6 activity.
作者： Christine Bouchardy , Simone Benhamou , Pierre Dayer
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摘要: The genetically determined P450 CYP2D6 activity is suspected to be involved in lung carcinogenesis by activating carcinogens contained tobacco smoke. Therefore, cancer risk should depend on both smoking exposure and activity. extent which activity, using dextromethorphan, could modify the effect of was evaluated from a study 128 cancers 157 controls. A strong interaction observed; rose with increasing (P < 0.001). Increasing levels increased only among smokers highest factor heavy smokers. Smokers daily consumption were at very high for cancer. These results may explain discrepant previous studies association between
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