Human Coronavirus Infections

摘要: The first report of a human coronavirus was in 1965 when Tyrrell and Bynoe (1965) isolated virus from the nasal washings male child. child had typical symptoms signs common cold washing found to be able induce colds volunteers challenged intranasally. virus, termed B814 (after number washing), could cultivated embryo tracheal organ tissue but not cell lines used at that time for growing other known etiologic agents cold. At same time, Hamre Procknow (1966) were characterizing five “new” respiratory tract medical students with colds. One these agents, strain 229E, adapted grow WI-38 cells. Subsequently, Almeida (1967) showed isolates morphologically identical viruses avian bronchitis mouse hepatitis. Mcintosh colleagues (1967a), working National Institutes Health Bethesda, then six related monolayer culture would cultures. Two isolates, OC (for culture) 38 43 suckling mice brain. term “Coronavirus,” which described characteristic morphology accepted 1968 (Tyrrell et al., 1968a).