Aldo-keto reductases and toxicant metabolism

摘要: SECTION 1: GENERAL OVERVIEW 1. Introduction and Overview of the Aldo-Keto Reductase (AKR) Superfamily 2: AKRS AND ENDOGENOUS TOXICANTS 2. Reductase-Catalyzed Detoxication Endogenous Aldehydes Associated With Diabetic Complications 3. Aldose Detoxifies Lipid Their Glutathione Conjugates 4. Role in Detoxification Oxidized Phospholipids 3: EXOGENOUS TOXICANTS: TOBACCO RELATED CARCINOGENS 5. Competing Roles Reductases Tobacco-Specific Nitrosamine Ketone NNK 6. Metabolic Activation Polycyclic Aromatic Hydrocarbons 7. Molecular Cloning Characterization Dihydrodiol Dehydrogenase from Mouse 8 Efficient Synthesis Active Metabolites Carcinogenic 9. Chemistry PAH o-Quinones Generated by AKR Pathway 10. Analysis Etheno-2'-Deoxyguanosine Adducts as Dosimeters Mediated Oxidative Stress 4: MYCOTOXINS, ALDEHYDES KETONES 11. Aflatoxin Aldehyde 12. Reactions B1-Dialdehyde: Enzymatic Reduction vs Adduction with Lysine 13. The use mammalian cell lines to investigate role aldo-keto reductases detoxication aldehydes ketones 5: AKRS, THE STRESS RESPONSE CELL SIGNALING 14. Response 15. Regulates Reactive Oxygen Species Mediated-Inflammatory Signals 16. Budding Yeast Saccharomyces cerevisiae