Association between childhood atopic dermatitis, malnutrition, and low bone mineral density: A US population‐based study

摘要: Background Children with atopic dermatitis (AD) have multiple risk factors for low bone mineral density (BMD). Methods We analyzed data from 3049 children and adolescents aged 8–19 yrs the 2005–2006 National Health Nutrition Examination Survey, including a cross-sectional questionnaire, dual energy X-ray absorptiometry, blood samples. Results In multivariate models that controlled age, sex, race/ethnicity, level of education household income, body mass index (BMI), smoking in household, AD was associated lower BMD z-score total femur (survey linear regression; adjusted β [95% CI]: −0.42 [0.68, −0.16]), trochanter (−0.29 [−0.54, −0.05]) femoral neck [−0.53, lumbar spine (−0.31 [−0.52, −0.11]). Children had higher median levels serum IgE (110.0 vs. 53.0 kU/l), peripheral lymphocyte (2.9 2.5 × 103 cells/μl), eosinophil counts (0.3 0.2 × 103 cells/μl) (Mann–Whitney U-test, p ≤ 0.003 all), but not CRP (0.03 0.04 mg/dl) odds 25-OH vitamin D deficiency logistic ratio [OR] 4.81 [1.21, 20.81]), calcium (2.56 [1.24, 5.28]), alkaline phosphatase [1.20, 5.44]), tertiles LDH (tertile 2: 6.36 [1.75, 23.18]; tertile-3: 4.57 [1.32, 15.85]), parathyroid hormone (PTH) or albumin. Finally, rates BMD, is, <−2, (23.4% 18.4%) (35.3% 24.5%). In regression and/or using stepwise selection 30 sociodemographic clinical factors, laboratory values, medications used, remained significant covariate (1.33 [1.32–1.34]). The covariates largest effects on were PTH albumin, basophil count, Hispanic ethnicity, BMI <5th percentile. Among AD, 56.2% those origin, 52.8% percentile, 75.0% 54.0% BMD. Conclusions Children particularly malnutrition ethnicity.