Method enabling use of extracellular RNA extracted from plasma or serum to detect, monitor or evaluate cancer

摘要: This invention relates to the use of tumor-derived or associated extracellular ribonucleic acid (RNA) found circulating in plasma serum fraction blood for detection, monitoring, evaluation cancer premalignant conditions. Extracellular RNA may circulate as non-bound RNA, protein-bound lipid-RNA complexes, lipoprotein (proteolipid)—RNA protein-RNA complexes including within association with ribonucleoprotein nucleosomes, apoptotic bodies. Any intracellular can additionally be detected by this invention. Specifically, enables extraction from and utilizes nucleic amplification assays identification, inference, any neoplasm, benign, premalignant, malignant, humans other animals, which might that RNA. Further, allows qualitative quantitative detection animals without prior knowledge presence tissue.