Seminoma with conspicuous signet ring cells: a rare, previously uncharacterized morphologic variant.

摘要: We report 2 seminomas with conspicuous numbers of signet ring cells. The tumors occurred in men, 24 and 69 years age, who presented testicular masses; 1 seminoma was a component mixed germ cell tumor the other pure. cells multifocal fashion areas otherwise typical comprised approximately 70% 10%, respectively, tumors. They had large, translucent to clear cytoplasmic vacuoles that compressed nuclei peripheral crescent. In case, contained numerous refractile, nonpolarizable globular deposits were shown be glycogen on basis periodic acid-Schiff stain positivity abolished by pretreatment diastase; second they mostly appeared "empty" lacked positivity. mucicarmine, cytokeratin (AE1/3) alpha-fetoprotein negative, but positive for OCT3/4 CD117, latter being expected A review 30 randomly selected identified very rare, inconspicuous 43%. presence prominent may cause confusion as it has not been described previously detail, variety neoplasms, particularly metastasis, considered. description this phenomenon expands known morphologic spectrum most common neoplasm.