Thiopurine S-methyltransferase and inosine triphosphate pyrophosphohydrolase genes in Japanese patients with inflammatory bowel disease in whom adverse drug reactions were induced by azathioprine/6-mercaptopurine treatment
作者： Kan Uchiyama , Makoto Nakamura , Takahiro Kubota , Tateki Yamane , Kiyotaka Fujise
DOI: 10.1007/S00535-008-2307-1
关键词: Thiopurine methyltransferase 、 ITPA 、 Pharmacology 、 Azathioprine 、 Hepatology 、 Inflammatory bowel disease 、 Thiopurine S-Methyltransferase 、 Internal medicine 、 Mercaptopurine 、 Medicine 、 Colitis 、 Gastroenterology
摘要: Background The main cause of azathioprine (AZA)/6-mercaptopurine (6MP)-induced adverse reactions is a reduction in the activities metabolizing enzymes thiopurine S-methyltransferase (TPMT) and inosine triphosphate pyrophosphohydrolase (ITPA). Adverse develop at high frequency Japanese patients half dose required for European American patients; however, association with TPMT ITPA gene polymorphisms has not been fully investigated.
springer.com
sci-hub.se 参考文章(29)
J. H. BURCHENAL, M. L. MURPHY, R. R. ELLISON, M. P. SYKES, T. C. TAN, L. A. LEONE, D. A. KARNOF-SKY, L. F. CRAVER, H. W. DARGEON, C. P. RHOADS, Clinical evaluation of a new antimetabolite, 6-mercaptopurine, in the treatment of leukemia and allied diseases. Blood. ,vol. 8, pp. 965- 999 ,(1953) , 10.1182/BLOOD.V8.11.965.965
Claudia Marx, Christine Fischer, Thomas Lang, Christoph Behrens, Michael Gregor, Michel Eichelbaum, Ulrich Zanger, Bernd Kaskas, Matthias Schwab, Elke Schaffeler, Azathioprine therapy and adverse drug reactions in patients with inflammatory bowel disease: impact of thiopurine S-methyltransferase polymorphism Pharmacogenetics. ,vol. 12, pp. 429- 436 ,(2002) , 10.1097/00008571-200208000-00003
Gertrude B. Elion, Stephen S. Sternberg, Donald A. Clarke, George H. Hitchings, C. Chester Stock, Frederick S. Philips, 6-Mercaptopurine: effects in mouse sarcoma 180 and in normal animals. Cancer Research. ,vol. 13, pp. 593- 604 ,(1953)
Richard M. Weinshilboum, Susan L. Sladek, Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity. American Journal of Human Genetics. ,vol. 32, pp. 651- 662 ,(1980)
E. Y. Krynetski, N. F. Krynetskaia, T. Loennechen, M. Y. Fessing, Hung-Liang Tai, C. R. Yates, W. E. Evans, Thiopurine S-methyltransferase deficiency : Two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians American Journal of Human Genetics. ,vol. 58, pp. 694- 702 ,(1996)
E E S Nieuwenhuis, J G Kusters, C J van der Woude, J M van Dieren, E J Kuipers, A J van Vuuren, ITPA genotyping is not predictive for the development of side effects in AZA treated inflammatory bowel disease patients Gut. ,vol. 54, pp. 1664- 1664 ,(2005)
A. Ansari, C. Hassan, J. Duley, A. Marinaki, E. -M. Shobowale-Bakre, P. Seed, J. Meenan, A. Yim, J. Sanderson, Thiopurine methyltransferase activity and the use of azathioprine in inflammatory bowel disease Alimentary Pharmacology & Therapeutics. ,vol. 16, pp. 1743- 1750 ,(2002) , 10.1046/J.1365-2036.2002.01353.X
Masahiro Hiratsuka, Tomoko Inoue, Fumiko Omori, Yasuyuki Agatsuma, Michinao Mizugaki, Genetic analysis of thiopurine methyltransferase polymorphism in a Japanese population. Mutation Research. ,vol. 448, pp. 91- 95 ,(2000) , 10.1016/S0027-5107(00)00004-X
T. Kubota, K. Chiba, Frequencies of thiopurine S-methyltransferase mutant alleles (TPMT*2, *3A, *3B and *3C) in 151 healthy Japanese subjects and the inheritance of TPMT*3C in the family of a propositus. British Journal of Clinical Pharmacology. ,vol. 51, pp. 475- 477 ,(2001) , 10.1046/J.1365-2125.2001.01371.X
Kazuhiko Kumagai, Keiko Hiyama, Shinichi Ishioka, Hiroe Sato, Yuji Yamanishi, Howard L. McLeod, Futoshi Konishi, Hiroyuki Maeda, Michio Yamakido, Allelotype frequency of the thiopurine methyltransferase (TPMT) gene in Japanese. Pharmacogenetics. ,vol. 11, pp. 275- 278 ,(2001) , 10.1097/00008571-200104000-00012