Human leukocyte and fibroblast interferons are structurally related.

作者: Tadatsugu Taniguchi , Ned Mantei , Marco Schwarzstein , Shigekazu Nagata , Masami Muramatsu

DOI: 10.1038/285547A0

关键词: BiologyGeneRecombinant DNAAmino acidRNANucleotideFibroblastMolecular biologyDNAPeptide sequence

摘要: The coding sequences of the dDNAs cloned human leukocyte interferon I and fibroblast show homologies 45% at nucleotide 29% amino acid level. We conclude that two genes were derived from a common ancestor.

参考文章(27)
William E. Stewart, The Interferon System ,(1979)
P J Bridgen, C B Anfinsen, L Corley, S Bose, K C Zoon, U T Rüegg, C E Buckler, Human lymphoblastoid interferon. Large scale production and partial purification. Journal of Biological Chemistry. ,vol. 252, pp. 6585- 6587 ,(1977) , 10.1016/S0021-9258(17)39886-1
E A Havell, S Yamazaki, J Vilcek, Altered molecular species of human interferon produced in the presence of inhibitors of glycosylation. Journal of Biological Chemistry. ,vol. 252, pp. 4425- 4427 ,(1977) , 10.1016/S0021-9258(17)40285-7
Y.H. Tan, F. Barakat, W. Berthold, H. Smith-Johannsen, C. Tan, The Isolation and Amino Acid/Sugar Composition of Human Fibroblastoid Interferon Journal of Biological Chemistry. ,vol. 254, pp. 8067- 8073 ,(1979) , 10.1016/S0021-9258(18)36051-4
William E. Stewart, Marzenna Wiranowska-Stewart, Vesa Koistinen, Kari Cantell, Effect of glycosylation inhibitors on the production and properties of human leukocyte interferon. Virology. ,vol. 97, pp. 473- 476 ,(1979) , 10.1016/0042-6822(79)90359-3
K. Zoon, M. Smith, P. Bridgen, C. Anfinsen, M. Hunkapiller, L. Hood, Amino Terminal Sequence of the Major Component of Human Lymphoblastoid Interferon Science. ,vol. 207, pp. 527- 528 ,(1980) , 10.1126/SCIENCE.7352260
Teresa G. Hayes, Y.K. Yip, Jan Vilček, Le interferon production by human fibroblasts Virology. ,vol. 98, pp. 351- 363 ,(1979) , 10.1016/0042-6822(79)90558-0
T. Taniguchi, S. Ohno, Y. Fujii-Kuriyama, M. Muramatsu, The nucleotide sequence of human fibroblast interferon cDNA. Gene. ,vol. 10, pp. 11- 15 ,(1980) , 10.1016/0378-1119(80)90138-9