The enigma of insulin resistance and hypertension: Insulin resistance, blood pressure, and the circulation

摘要: The epidemiologic link between obesity and hypertension is more clearly emerging to be one insulin resistance hypertension. Relative occurs not only in obese hypertensive patients but also non-obese lean essential patients. Although has complex actions on the circulation, plausible mechanisms by which might raise blood pressure include renal sodium retention stimulation of sympathetic nervous system. However, evidence that can actually long-term lacking. Since does develop all or insulin-resistant subjects, relationship must modulated other genetic environmental factors. Obesity, diminished physical conditioning, aging, diabetes are ubiquitous contributors relative associated with a tendency for rise. Conditions agents acquired secondary forms pregnancy, oral contraceptives, acromegaly, glucocorticoids. type 2 non-insulin-dependent state increased resistance, partly sustained mechanisms. Future research should identify determinants utilize these therapy.