Elevated hepatic insulin extraction in essential hypertension.

摘要: Insulin resistance, hyperinsulinemia, and dyslipidemia are common characteristics of patients with untreated hypertension. However, the link between vascular metabolic disturbances is still unclear. To provide further insights into picture subjects hypertension, we evaluated insulin pancreatic secretion, hepatic extraction hormone in 16 essential hypertension before after 12-16 weeks drug treatment comparison age-, sex-, body weight-matched normotensive control subjects. All underwent an oral a frequently sampled intravenous glucose tolerance test. Metabolic parameters were calculated by minimal model technique. The hypertensive exhibited highly reduced tissue sensitivity (2.6 +/- 0.4 versus 9.6 1.9 10(4) min-1/[microunits/mL]; p < 0.001). basal secretion rate (70 11 35 5 pmol/L per minute) total amount prehepatically secreted (32 4 2 nmol/L hours) significantly increased compared (p 0.01), whereas posthepatic delivery was not different two groups (4.9 0.6 3.5 0.3 hours). Hepatic found to be elevated (81 4% 69 3%, 0.04). Increased partially ameliorated B cell hypersecretion patients. After treatment, blood pressure normalized, but profile remained unchanged. We conclude that liver specific characteristic individuals compensates hypersecretion.