Insulin resistance in hypertension quantified by oral glucose tolerance test: comparison of methods.

摘要: Four methods reported in the literature for evaluation of insulin sensitivity indexes from oral glucose tolerance tests (OGTTs) were analyzed and compared order to test their ability discriminate insulin-resistant state hypertension. To this aim, 15 normoglycemic subjects, not affected by metabolic syndrome, underwent a 22-sample, 300-minute OGTT. Eight subjects normotensive (mean age, 47.0 +/- 4.2 years) 7 hypertensive 53.6 1.6 years). The following computed compared: (a) 2 indexes, ISIE22/300 ISIE8/180, provided an integral equation (IE) method applied full OGTT reduced 8-sample, 180-minute data subset, respectively; (b) ISOGIS180 ISOGIS120, glucose, (OGIS) method, which only requires 3 blood samples taken within 180 120 minutes, (c) index, ISISI, considers fasting mean insulinemia glycemia measured during 5-sample, 120-minute OGTT; (d) ISMCR, body mass index minutes. Except ISOGIS180, all other able detect significant reduction (unpaired Student t test, P < .05) our group with group. Failure was explained fact that did capture information portrayed peak patients, occurred around 90th minute. Intraclass correlation coefficients higher than 0.89 demonstrated substantial agreement between ISIE8/180 indexes. These are characterized units measure consistent definition as enhance effectiveness.