Taxol in advanced, hormone-refractory carcinoma of the prostate. A phase II trial of the eastern cooperative oncology group
作者： Bruce J. Roth , Patrick J. Loehrer , Beow Yong Yeap , George Wilding , Basil Kasimis
DOI: 10.1002/1097-0142(19931015)72:8<2457::AID-CNCR2820720825>3.0.CO;2-Z
关键词: Prostate 、 Prostate cancer 、 In patient 、 Clinical trial 、 Oncology 、 Hormone refractory 、 Carcinoma 、 Medicine 、 Chemotherapy 、 Internal medicine 、 Stable Disease
摘要: Background. Recent clinical trials have documented activity for combinations of chemotherapeutic agents that target the microtubular apparatus in patients with hormone-refractory prostate cancer. Taxol has a novel antimicrotubular mechanism, acting by stabilizing polymerized tubulin. Methods. Twenty-three cancer and bidimensionally measurable disease were treated 24-hour continuous infusion at 135-170 mg/M2 every 21 days maximum 6 cycles. Results. Eighty-five courses administered to 23 patients. One patient (4.3%) experienced partial response lasting 9 months, four other radiographically stable had minor reduc
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