Taxoids and Multidrug Resistance

摘要: Taxol is now recognized as one of the most interesting and promising new drugs derived from natural products to enter clinical trials for treatment cancer in many years. Its importance international movement preserve biodiversity has been profound far-reaching, it represents proof potential value products, particularly those rapidly disappearing forests this planet (Junod 1991). Originally regarded tree death, toxic constituents portions yew were known long ago time Julius Caesar (Kingston 1994). Tales poison associated with bark western (Taxus brevifolia), an evergreen found Pacific Northwest, told years by native Americans but antitumor activity taxol present within itself was discovered only recently (Suffness 1989). The small, slow-growing little commercial generally cut burned larger more valuable fir, spruce pine trees are harvested.