Decoding and reprogramming complex polyketide assembly lines: prospects for synthetic biology
DOI: 10.1016/J.TIBS.2015.02.001
关键词: Genome mining 、 Polyketide 、 Synthetic biology 、 Reprogramming 、 Computational biology 、 Biology 、 Mechanism (biology) 、 Structural diversity 、 Combinatorial chemistry
摘要: … of the molecular structures hampers their chemical synthesis … PKSs) that were first discovered in actinomycetes, there is an … (A) Enzymatic formation of oxygen heterocycles mediated by …
elsevier.com
sci-hub.se 参考文章(81)
Bradley S Moore, Christian Hertweck, Biosynthesis and attachment of novel bacterial polyketide synthase starter units Natural Product Reports. ,vol. 19, pp. 70- 99 ,(2002) , 10.1039/B003939J
Evgeny V. Prusov, Total synthesis of antibiotics: recent achievements, limitations, and perspectives. Applied Microbiology and Biotechnology. ,vol. 97, pp. 2773- 2795 ,(2013) , 10.1007/S00253-013-4757-5
Hai-Yan He, Hai-Xue Pan, Long-Fei Wu, Bei-Bei Zhang, Han-Bo Chai, Wen Liu, Gong-Li Tang, Quartromicin Biosynthesis: Two Alternative Polyketide Chains Produced by One Polyketide Synthase Assembly Line Chemistry & Biology. ,vol. 19, pp. 1313- 1323 ,(2012) , 10.1016/J.CHEMBIOL.2012.07.024
Daniel Heine, Tom Bretschneider, Srividhya Sundaram, Christian Hertweck, Enzymatic Polyketide Chain Branching To Give Substituted Lactone, Lactam, and Glutarimide Heterocycles Angewandte Chemie. ,vol. 53, pp. 11645- 11649 ,(2014) , 10.1002/ANIE.201407282
Shunji Takahashi, Atsushi Toyoda, Yasuyo Sekiyama, Hiroshi Takagi, Toshihiko Nogawa, Masakazu Uramoto, Ryuichiro Suzuki, Hiroyuki Koshino, Takuto Kumano, Suresh Panthee, Tohru Dairi, Jun Ishikawa, Haruo Ikeda, Yoshiyuki Sakaki, Hiroyuki Osada, Reveromycin A biosynthesis uses RevG and RevJ for stereospecific spiroacetal formation Nature Chemical Biology. ,vol. 7, pp. 461- 468 ,(2011) , 10.1038/NCHEMBIO.583
Nick Quade, Liujie Huo, Shwan Rachid, Dirk W Heinz, Rolf Müller, Unusual carbon fixation gives rise to diverse polyketide extender units Nature Chemical Biology. ,vol. 8, pp. 117- 124 ,(2012) , 10.1038/NCHEMBIO.734
Sean Poust, Andrew Hagen, Leonard Katz, Jay D Keasling, Narrowing the gap between the promise and reality of polyketide synthases as a synthetic biology platform. Current Opinion in Biotechnology. ,vol. 30, pp. 32- 39 ,(2014) , 10.1016/J.COPBIO.2014.04.011
Georg Zocher, Martin E. A. Richter, Uwe Mueller, Christian Hertweck, Structural fine-tuning of a multifunctional cytochrome p450 monooxygenase. Journal of the American Chemical Society. ,vol. 133, pp. 2292- 2302 ,(2011) , 10.1021/JA110146Z
Satoshi Yuzawa, Woncheol Kim, Leonard Katz, Jay D Keasling, Heterologous production of polyketides by modular type I polyketide synthases in Escherichia coli Current Opinion in Biotechnology. ,vol. 23, pp. 727- 735 ,(2012) , 10.1016/J.COPBIO.2011.12.029
Jordan L. Meier, Michael D. Burkart, The chemical biology of modular biosynthetic enzymes Chemical Society Reviews. ,vol. 38, pp. 2012- 2045 ,(2009) , 10.1039/B805115C