Twofold polyketide branching by a stereoselective enzymatic Michael addition.
作者： Daniel Heine , Srividhya Sundaram , Tom Bretschneider , Christian Hertweck
DOI: 10.1039/C5CC03085D
关键词:
摘要: The versatility of the branching module rhizoxin polyketide synthase was tested in an vitro enzyme assay with a mimic and branched (di)methylmalonyl-CoA extender units. Comparison products synthetic reference compounds revealed that is able to stereoselectively introduce two branches one step by Michael addition–lactonisation sequence, thus expanding scope previously studied PKS systems.
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