Platelet-derived growth factor receptor/platelet-derived growth factor (PDGFR/PDGF) system is a prognostic and treatment response biomarker with multifarious therapeutic targets in cancers
作者： Kwaku Appiah-Kubi , Ying Wang , Hai Qian , Min Wu , Xiaoyuan Yao
DOI: 10.1007/S13277-016-5069-Z
关键词: Biology 、 Tyrosine kinase 、 Platelet-derived growth factor 、 Cancer 、 Cancer research 、 Biomarker (cell) 、 Growth factor receptor 、 Immunology 、 Receptor tyrosine kinase 、 Platelet-derived growth factor receptor 、 Receptor
摘要: Progress in cancer biology has led to an increasing discovery of oncogenic alterations the platelet-derived growth factor receptors (PDGFRs) cancers. In addition, their overexpression numerous cancers invariably makes PDGFRs and factors (PDGFs) prognostic treatment markers some The oncologic PDGFR/PDGF system affect extracellular, transmembrane tyrosine kinase domains as well juxtamembrane segment receptor. receptor is also involved fusions with intracellular proteins kinase. These discoveries undoubtedly make attractive therapeutic target. This review covers elementary its role a marker multifarious targets are discussed. Great potential exists for further exploration safe efficacious management treatments.
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