Chitosan (or alginate)-coated iron oxide nanoparticles: A comparative study

摘要: Abstract The preparation and characterization of stable aqueous suspensions superparamagnetic iron oxide nanoparticles stabilized with chitosan (CHI) or alginate (ALG) are reported. Particles were synthesized via a controlled co-precipitation method. particles obtained had diameter ∼12 nm; value that ensures properties their suitability for biomedical applications. optimal concentration polymer needed coating the was determined using adsorption isotherms. When magnetic coated CHI ALG, compared through following measurements: hydrodynamic ratio; ζ-potential; content particles, by thermogravimetry; properties; high-resolution transmission electron microscopy; and, finally, stability in biological media. ALG-coated mean 50–55 nm, whereas CHI-coated 80–120 nm. Both types showed similar values saturation magnetization (59.3 emu g−1 nanoparticles; 56.8 emu g−1 ones); however, when contact human multisera at 37 °C, significant differences observed between two. up to 9 days, while only 2 days. Agglomeration phase separation main effects observed.