Very low prevalence of XPD K751Q polymorphism and its association with XPD expression and outcomes of FOLFOX‐4 treatment in Asian patients with colorectal carcinoma

摘要: Xeroderma pigmentosum group D (XPD) participates in DNA unwinding during nucleotide excision repair, which may alter the efficacy of platinum-based chemotherapy. We analyzed influence codon 751 LysGln polymorphism XPD on its protein expression levels, clinico-pathological features, and outcome 188 Chinese patients with metastatic colorectal carcinoma (CRC) that had been treated first-line Oxaliplatin + Leucovorin + 5-Fluorouracil (FOLFOX-4) The results showed comparison Caucasian populations, a remarkably lower prevalence Lys/Gln genotype was noted (16%, n = 30). No between-group difference or without this (56.5%vs 59.7%; P = 0.783). Patients Gln751 allele have significantly response to FOLFOX-4 treatment (36.7%vs 58.2%, P = 0.03), shorter progression-free (7 vs 11 months; P < 0.01) overall (14 vs 22 months; survivals. incidence grade 3/4 oxaliplatin-neuropathies very similar both groups (13.3%vs 16.5%; P = 0.67). By adjusted analysis, further identified as an independent prognostic factor (P = 0.03). These data suggest Asian populations XPD, could be key determinant for good oxaliplatin-based favorable outcomes. (Cancer Sci 2009; 100: 1261–1266)