Immune surveillance of human cancer: If the cytotoxic T-lymphocytes play the music, does the tumoral system call the tune?

摘要: Accumulating evidence indicates that the innate and adaptive immune systems participate in recognition destruction of cancer cells by a process known as immunosurveillance. Tumor antigen-specific cytotoxic T-lymphocytes (CTL) are major effectors response against tumor cells. The identification tumor-associated antigen (TAA) recognized primarily CD 8(+) has led to development several vaccination strategies induce or potentiate specific responses. However, large established tumors, which associated with acquisition resistance lysis, usually not fully controlled system. Recently, it become clear system only protects host but also sculpts immunogenic phenotype developing can favor emergence resistant cell variants. Moreover, obvious evasion immunosurveillance is under control microenvironment complexity plasticity. In this review, we will focus on some new mechanisms lysis during progression, involving genetic instability, structural changes cytoskeleton, hypoxic stress. We discuss interaction between CTLs endothelial cells, component stroma.