LincRNA FEZF1-AS1 contributes to the proliferation of LAD cells by silencing p57 expression

摘要: // Shuai Jin 1 , Siyu Chen Yongfu Ma Bo Yang and Liu Department of Thoracic surgery, PLA General Hospital, Beijing, 100853 China Correspondence to: Liu, email: liuyang_ly04@163.com Keywords: lung adenocarcinoma, FEZF1-AS1, LSD1, EZH2, H3K4me2 Received: May 23, 2017      Accepted: September 05, Published: 2017 ABSTRACT LincRNA FEZF1-AS1 has been identified to exert oncogenic functions in various biological processes tumorigenesis. However, the function adenocarcinoma still remains unclear. Our findings revealed that was increased tissues cell lines high level associated with poor prognosis adenocarcinoma. Functional experiments mechanistic investigations demonstrated knockdown significantly repressed proliferation through influencing distribution cycle. Besides, we also uncovered could suppress p57 expression recruiting EZH2 LSD1 promoter p57, thus influenced cycle proliferation. Collectively, our results suggested involved progression might be as a potential therapy target for human