Intracranial haemorrhages associated with venom induced consumption coagulopathy in Australian snakebites (ASP-21).
作者： Ingrid Berling , Simon G.A. Brown , Ferdi Miteff , Christopher Levi , Geoffrey K. Isbister
DOI: 10.1016/J.TOXICON.2015.05.012
关键词: Coagulopathy 、 Snake envenoming 、 Venom-induced consumption coagulopathy 、 Pediatrics 、 Snake bites 、 Anesthesia 、 Consumption Coagulopathy 、 Antivenom 、 Cohort 、 Vomiting 、 Medicine
摘要: Abstract Intracranial haemorrhage (ICH) is a rare life-threatening consequence of venom induced consumption coagulopathy in snake-bite. It unclear why certain patients haemorrhage. We aimed to investigate ICH snake envenoming. Cases venom-induced from July 2005–June 2014 were identified the Australian Snakebite Project, prospective multicentre cohort snake-bites. with extracted data on snake-bite, clinical effects, laboratory investigations, treatment and outcomes. 552 cases had coagulopathy; median age, 40 y (2–87 y), 417 (76%) males, 253 (46%) brown snakes 17 died (3%). There 6/552 (1%) ICH; 71 y (59–80 y), three males five snakes. All received antivenom died. six history hypertension. Time onset effects consistent was 8–12 h four cases, within 3 h two. Difficult manage hypertension vomiting common. One patient normal cerebral CT presentation after focal neurological repeat showed an ICH. snake-bite only 1% developing one. Older age associated
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