Mechanisms of oral tolerance by MHC peptides.

摘要: Recent evidence indicates that MHC peptides play an important role in T-cell recognition of alloantigen. We studied the tolerogenicity orally administered synthetic allopeptides rat model. Initially, we demonstrated oral administration class II significantly inhibited DTH response to as well donor-derived cells. The tolerogenic effect was antigen specific and induced by immunogenic, but not nonimmunogenic, allopeptides. Immunohistological studies skin lesions showed tolerance is associated with a state "immune deviation" predominance Th2 cell function lesions. recently extended above observations examined on MLR CTL generation. found effected significant reduction proliferation generation, which specific. In addition, similar results when compared immunogenic versus nonimmunogenic peptides, suppression higher peptides. gut immune system Initial experiments intestinal epithelial cells pulsed vitro allopeptides, or vivo were capable presenting these primed T vitro. Whether such presentation other antigen-presenting leads preferential activation regulatory cells, ultimately suppress Th1 alloimmune responses, remains be determined.