The relative contribution of direct and indirect antigen recognition pathways to the alloresponse and graft rejection depends upon the nature of the transplant.
作者： Ben M Illigens , Akira Yamada , Eugenia V Fedoseyeva , Natalie Anosova , Florence Boisgerault
DOI: 10.1016/S0198-8859(02)00449-4
关键词:
摘要: Abstract In this study, we measured direct and indirect T-cell alloresponses mediated by CD4 + CD8 T cells in three mouse transplantation models: skin, cornea, retina. We show that the contribution of antigen recognition pathways to alloresponse fully allogeneic grafts varies depending upon nature tissue/organ transplanted. The implications finding for understanding cellular mechanisms which rejection is different transplant models are discussed.
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