Presynaptic Actions of Nicotine in the CNS
作者： S. Wonnacott , A. L. Drasdo
DOI: 10.1007/978-3-0348-7457-1_40
关键词: Stimulation 、 Nicotine 、 Dopamine 、 Receptor 、 Nicotinic acetylcholine receptor 、 Pharmacology 、 Acetylcholine receptor 、 Nicotinic agonist 、 Binding site 、 Chemistry
摘要: Nicotine stimulates the release of neurotransmitters in CNS. One locus its action is directly on nerve terminal, through presynaptic nicotinic acetylcholine receptors. The stimulation dopamine from striatal terminals has been particularly widely studied. acts a dose-dependent manner (EC50=4µM) to elicit Ca2+-dependent release. pharmacological profile this favours ganglionic type receptor, but molecular biological techniques have revealed several subtypes receptors specificity nicotine-evoked transmitter consistent with receptor class identified by high affinity [3H]nicotine binding. This correlation supported loss such binding sites following degeneration after lesion experiments or degenerative diseases, and subcellular fractionation expermients indicate that proportion are associated isolated terminals. Thus may constitute major target nicotine brain.
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E S Deneris, J Boulter, J Connolly, E Wada, K Wada, D Goldman, L W Swanson, J Patrick, S Heinemann, Genes encoding neuronal nicotinic acetylcholine receptors. Clinical Chemistry. ,vol. 35, pp. 731- 737 ,(1989) , 10.1093/CLINCHEM/35.5.731
MH Jacob, DK Berg, The ultrastructural localization of alpha-bungarotoxin binding sites in relation to synapses on chick ciliary ganglion neurons The Journal of Neuroscience. ,vol. 3, pp. 260- 271 ,(1983) , 10.1523/JNEUROSCI.03-02-00260.1983
Kathleen M. Wolf, Anita Ciarleglio, Vincent A. Chiappinelli, κ-Bungarotoxin: binding of a neuronal nicotinic receptor antagonist to chick optic lobe and skeletal muscle Brain Research. ,vol. 439, pp. 249- 258 ,(1988) , 10.1016/0006-8993(88)91481-3
David R.E. Macallan, George G. Lunt, Susan Wonnacott, Karen L. Swanson, Henry Rapoport, Edson X. Albuquerque, Methyllycaconitine and (+)-anatoxin-a differentiate between nicotinic receptors in vertebrate and invertebrate nervous systems FEBS Letters. ,vol. 226, pp. 357- 363 ,(1988) , 10.1016/0014-5793(88)81454-6
Etsuko Wada, Keiji Wada, Jim Boulter, Evan Deneris, Steve Heinemann, Jim Patrick, Larry W. Swanson, Distribution of alpha2, alpha3, alpha4, and beta2 neuronal nicotinic receptor subunit mRNAs in the central nervous system: A hybridization histochemical study in the rat The Journal of Comparative Neurology. ,vol. 284, pp. 314- 335 ,(1989) , 10.1002/CNE.902840212
Susan Wonnacott, α‐Bungarotoxin Binds to Low‐Affinity Nicotine Binding Sites in Rat Brain Journal of Neurochemistry. ,vol. 47, pp. 1706- 1712 ,(1986) , 10.1111/J.1471-4159.1986.TB13078.X
Ralf Schoepfer, William G. Conroy, Paul Whiting, Martin Gore, Jon Lindstrom, Brain α-bungarotoxin binding protein cDNAs and MAbs reveal subtypes of this branch of the ligand-gated ion channel gene superfamily Neuron. ,vol. 5, pp. 35- 48 ,(1990) , 10.1016/0896-6273(90)90031-A
Paul B.S. Clarke, Agu Pert, Autoradiographic evidence for nicotine receptors on nigrostriatal and mesolimbic dopaminergic neurons Brain Research. ,vol. 348, pp. 355- 358 ,(1985) , 10.1016/0006-8993(85)90456-1
Mann Xu, Takeshi Kato, Brain dialysis: changes in the activities of dopamine neurons in rat striatum by perfusion of acetylcholine agonists under freely moving conditions Neurochemistry International. ,vol. 12, pp. 539- 545 ,(1988) , 10.1016/0197-0186(88)90040-X
Ralph H. Loring, Richard E. Zigmond, Characterization of neuronal nicotinic receptors by snake venom neurotoxins. Trends in Neurosciences. ,vol. 11, pp. 73- 78 ,(1988) , 10.1016/0166-2236(88)90168-3