Genes encoding neuronal nicotinic acetylcholine receptors.

摘要: Four genes (alpha 2, alpha 3, 4, and beta 2), which encode proteins homologous to the Torpedo electric organ vertebrate muscle nicotinic acetylcholine receptors, have been identified by cloning rat brain cDNAs. Injection of transcripts derived from these cDNAs into Xenopus laevis oocytes results in formation three receptors. Two 3/beta 2 4/beta characteristics ganglionic The third 2/beta 2) exhibits a previously undescribed pharmacology thus represents novel subtype that may be expressed brain. wide distribution indicates neuronal receptors are major neurotransmitter receptor system.