Method to improve sensitivity of molecular binding assays using phase-sensitive luminescence detection
作者： Salvador M. Fernandez
DOI:
关键词: Molecular recognition 、 Molecular binding 、 Luminophore 、 Sensitivity (control systems) 、 Phase sensitive 、 Analytical chemistry 、 Luminescence 、 Materials science 、 Signal
摘要: An apparatus and method, which uses luminescence phase-sensitive detection, for improving the detection sensitivity of molecular recognition assays in analytical signal contains two components, each arising from a different state luminophore having characteristic lifetime that is other.
lens.org 参考文章(6)
Henryk Szmacinski, Joseph R. Lakowicz, Michael L. Johnson, Klaus W. Berndt, Kazimierz Nowaczyk, Method and apparatus for multi-dimensional phase fluorescence lifetime imaging ,(1992)
Henryk Szmacinski, Joseph R. Lakowicz, Fluorescence lifetime-based sensing and imaging. Sensors and Actuators B-chemical. ,vol. 29, pp. 16- 24 ,(1995) , 10.1016/0925-4005(95)01658-9
Shabbir B. Bambot, Joseph R. Lakowicz, Govind Rao, Potential applications of lifetime-based, phase-modulation fluorimetry in bioprocess and clinical monitoring Trends in Biotechnology. ,vol. 13, pp. 106- 115 ,(1995) , 10.1016/S0167-7799(00)88915-5
Henryk Szmacinski, Joseph R. Lakowicz, Method for optically measuring chemical analytes ,(1992)
Peter Joseph Jacques Parker, Philippe Igor Henri Bastiaens, Methods for detecting changes to cellular components ,(2000)
Douglas N. Modlin, John C. Owicki, Todd E. French, Apparatus and methods for improving signal resolution in optical spectroscopy ,(1999)