Effects of L-carnitine on mechanical recovery of isolated rat hearts in relation to the perfusion with glucose and palmitate.
作者： Heinz Lõster , Michael Punzel
关键词: Endocrinology 、 Clinical chemistry 、 Fatty acid 、 Hemodynamics 、 Cardiology 、 Carbohydrate metabolism 、 Carnitine 、 Perfusion 、 Ventricular pressure 、 Chemistry 、 Ischemia 、 Internal medicine
摘要: The purpose of this study was to investigate the effects L-carnitine on hemodynamic parameters Langendorff hearts. Isolated rat hearts were perfused with various solutions containing high or low concentrations fatty acids, additional glucose no glucose, and L-carnitine. most interesting part experiments behaviour in reperfusion period after no-flow ischemia 20 min. results were: (1) With acid showed an improved recovery left ventricular functions compared concentrations. Without pressure is much lower period. (2) Addition ischemically damaged This improvement especially impressive at addition but without strongly behaviour. (3) coronary flow increased by 2 experimental conditions: (i) perfusion levels carnitine (ii) acids glucose. These findings suggest that supplementation has a beneficial effect isolated heart under conditions, possibly specific human diseases.
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