Detailed gene copy number and RNA expression analysis of the 17q12-23 region in primary breast cancers.
作者： Simon Willis , Anne-Marie Hutchins , Fleur Hammet , John Ciciulla , Wee-Kheng Soo
DOI: 10.1002/GCC.10138
关键词: Regulation of gene expression 、 Biology 、 Copy-number variation 、 Comparative genomic hybridization 、 Gene 、 Gene duplication 、 Genetics 、 Gene dosage 、 Gene expression profiling 、 Carcinogenesis
摘要: Chromosome region 17q12-23 commonly shows an increase in DNA copy number breast cancers, suggesting that several oncogenes are located at this site. We performed a high-resolution expression array and comparative genomic hybridization analysis of genes mapped to the entire region, identify novel candidate oncogenes. identified 24 showed significant overexpression cancers with gain 17q12-23, compared without gain. These included previously oncogenes, together FISH using specific gene probes hybridized tissue arrays confirmed underlying amplification overexpressed genes. This indicates established including Wnt-signaling pathway member, amplified within individual primary cancer samples. were also able confirm presence two apparently separate reciprocally groups region. Investigation these their functional interactions will facilitate our understanding oncogenesis optimal management disease.
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