Tumor Hypoglycemia: Deficient Splanchnic Glucose Output and Deficient Glucagon Secretion

摘要: Fasting hypoglycemia occurred in a patient with histologically benign mesothelioma; the serum insulin was low (2-4 µU./ml.), as glucose utilization rate. Splanchnic output markedly decreased on direct measurement (21 mg./min.; normal: 108-180 mg./min.). uptake of gluconeogenic substrates plasma glucagon normal during and responded poorly to oral intravenous alanine. The nonsuppressible insulin-like (NSILA-s) somatomedin-like activities were not elevated, tumor did release activity incubation nor it contain somatostatin. marked decrease splanchnic principal cause hypoglycemia, associated an apparent glycogenolysis, at least partly due deficient secretion. relationship these defects is unclear. may have secreted unknown material affecting primarily liver and/or pancreatic alpha cell. approach used here serve paradigm for analysis caused by excessive insulin.