Axonal swellings in the corticospinal tracts in amyotrophic lateral sclerosis
作者： K. Okamoto , S. Hirai , M. Shoji , Y. Senoh , T. Yamazaki
DOI: 10.1007/BF00308929
关键词: Anatomy 、 Degenerative disease 、 Amyotrophic lateral sclerosis 、 Anterior horn 、 Biology 、 Autopsy 、 Pathology 、 Neurofilament 、 Corticospinal tract 、 Axon 、 Pathology and Forensic Medicine 、 Cellular and Molecular Neuroscience 、 Clinical neurology
摘要: In 2 of 16 cases with sporadic amyotrophic lateral sclerosis (ALS) large numbers axonal swellings were observed in the corticospinal tracts over a region extending from posterior limbs internal capsules to bulbar pyramids. On electron microscopy, these seen consist accumulations neurofilaments and altered neuronal organelles (mitochondria secondary lysosomes). Their morphology differed spheroids anterior horn ALS.
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