Kinetics of cellular proliferation after arterial injury. I. Smooth muscle growth in the absence of endothelium.

摘要: Abstract Intimal smooth muscle (SMC) proliferation was examined in the rat left carotid regions lacking endothelium for prolonged periods of time. Arteries animals injected with tritiated thymidine and Evans blue were at intervals between 0 12 weeks. The endothelial layer regenerated from ends denuded segment but failed to cover central third artery by Autoradiography on samples this region (stained blue) endothelialized (white) showed that SMC reached a maximum 48 hours media (46%) 96 intima (73%). Subsequently, index declined baseline (0.06%) 4 weeks throughout 8 covered endothelium. persisted high level (3.8%) surface even Despite continued luminal SMC, total arterial number same 2 These results support concept intimal after injury is an acute event related initial process. Persistent does not result increase cell number.