Mct protein inhibitor-related prognostic and therapeutic methods
作者： Federica Sotgia , Michael P. Lisanti
DOI:
关键词: Pathology 、 Cancer 、 Cancer research 、 Monocarboxylate transporter 、 Stromal cell 、 Tumor tissue 、 Proteinase inhibitor 、 Medicine
摘要: This invention provides a method of identifying one or more subgroups cancer patients that are likely to benefit from treatment with monocarboxylate transporter (MCT) protein inhibitor comprising: (a) obtaining sample cancer/tumor tissue each said patients; (b) determining the expression level stromal MCT4 in samples obtain first dataset; and (c) using dataset classify sets as MCT4-positive MCT4-negative, wherein classified MCT4- positive MCT inhibitor. also related methods for treating whose component expresses patient.
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