Fibroblast subpopulations as accelerators of tumor progression: The role of migration stimulating factor

摘要: Tumor progression is a relatively indolent process, with many years commonly intervening between the inception of an initiating genetic lesion and development overt malignant disease. We suggest that perturbation normal epithelial-mesenchymal interactions caused by inappropriate presence fibroblast subpopulations displaying various ‘fetal-like’ phenotypic characteristics may significantly alter kinetics tumor hence enhance susceptibility to cancer development. In this communication, we review our own data indicating fetal-like fibroblasts in patients put these observations context similar published reports. then discuss interpretation findings, emphasising possible direct involvement pathogenesis putting forward epigenetic ‘clonal modulation’ model account for their patients.